Molecular Stethoscope Announces Publication of its NAFLD/NASH Study in the American Journal of Physiology

Circulating cell-free mRNA in blood reflective of NAFLD/NASH liver pathology

PALO ALTO, Calif., Feb. 23, 2021 /CNW/ — Molecular Stethoscope, Inc., a precision drugs biotechnology firm, broadcasts publication of its human proof-of-concept research describing the stratification of NAFLD/NASH sufferers with clinically related and superior liver fibrosis utilizing the corporate’s Subsequent-Era cell-free mRNA Liquid Biopsy Expertise Platform. The research titled “Non-invasive Stratification of Non-Alcoholic Fatty Liver Illness by Entire-transcriptome Cell-free mRNA Characterization” was revealed within the American Journal of Physiology – Gastrointestinal and Liver Physiology, a journal of the American Physiological Society. The primary writer is Naga Chalasani, M.D., Professor of Gastroenterology and Hepatology and Interim Chair within the Division of Drugs at Indiana College within the USA. Dr. Chalasani is the main writer of the AASLD Apply Pointers for the prognosis and administration of NAFLD/NASH illness. “As soon as validated in bigger research, non-invasive Liquid Biopsy diagnostic options akin to those being developed by Molecular Stethoscope could also be used serially not solely as Drug Improvement Instruments to observe the continuing difficult pharmacotherapy medical trials, but in addition to observe cf-mRNA modifications throughout way of life modification which has led to marked enhancements in steatosis and fibrosis,” commented Dr. Chalasani.

There continues to be a concerted effort to speed up the interpretation of modern applied sciences to medical research and affected person administration. In step with this, the diligent efforts by the USA Nationwide Institute of Requirements and Expertise (NIST), biotechnology consortia and the USA-FDA have made foundational strides in establishing greatest observe Subsequent Era Sequencing, RNA-Seq and Machine Studying that may speed up the interpretation of the Molecular Stethoscope Expertise Platform into merchandise for medical observe.

The substantial unmet medical want in NAFLD/NASH has spurred a $1.4B funding by quite a few Pharma/Biotech firms with 125 interventional medical trials now recruiting topics. As well as, the USA-FDA has inspired the event of Drug Improvement Instruments to observe efficacy of pharmacotherapies that concentrate on a number of mechanisms of motion. “Medical interventional research for NAFLD/NASH have a number of challenges. The Liver Discussion board, a collaborative non-competitive group of stakeholders from academia, regulatory companies, skilled societies, affected person organizations, and trade stakeholders, has advisable commonplace reporting of baseline parameters and standardization of weight loss plan and train data to facilitate cross-trial evaluation, an essential step in validation of Non-Invasive Checks for this critical frequent power liver illness,” added Veronica Miller, Ph.D., the founder and Director of the Discussion board for Collaborative Analysis and a Professor (Adjunct) on the UC Berkeley College of Public Well being.

“The publication of this essential research positions us to maneuver ahead with the subsequent section of product growth to have a big impression on NAFLD/NASH medical observe and in Pharma/Biotech R&D to enhance the well being of sufferers,” commented Guillermo Elias, Ph.D., Chief Government Officer at Molecular Stethoscope.

The research is out there on the American Journal of Physiology – Gastrointestinal and Liver Physiology web site.

https://journals.physiology.org/doi/abs/10.1152/ajpgi.00397.2020

“We wish to thank the contributions of our medical and scientific collaborators and NAFLD/NASH sufferers for taking part on this research,” acknowledged Dr. Elias, CEO of Molecular Stethoscope.

About Molecular Stethoscope
Molecular Stethoscope is a precision drugs firm based mostly in Silicon Valley, California, centered on discovering, growing and commercializing non-invasive and dynamic merchandise for the early detection, prognosis and treatment-response monitoring of power illnesses beginning with the liver (NAFLD/NASH) and the central nervous system (Alzheimer’s Illness and A number of Sclerosis). Molecular Stethoscope was co-founded by Dr. Stephen Quake, Professor of Bioengineering at Stanford College, and co-President of the Chan Zuckerberg BioHub, and Dr. Eric Topol, Director and Founder, Scripps Analysis Translational Institute; Chair of Progressive Drugs, Scripps. The Firm’s proprietary and novel Subsequent-Era cf-mRNA Liquid Biopsy-Synthetic Intelligence Expertise Platform integrates cell-free mRNA (cf-mRNA) with RNA-Seq, medical data, and purpose-built bioinformatics and machine studying and synthetic intelligence to generate clinically actionable, dynamic data to basically change how healthcare is delivered at scale.

Ahead Trying Assertion
This press launch comprises forward-looking statements together with, however not restricted to statements in regards to the Firm’s expectations relating to its proprietary Expertise Platform. Ahead trying statements are topic to uncertainties that would trigger precise efficiency or outcomes to vary materially from these expressed within the forward-looking statements.

Extra data and inquiries

Investor Relations: [email protected]

Public and Media Relations: [email protected]

SOURCE Molecular Stethoscope, Inc.